Routine Quality Testing of Blood Platelet Transfusions with Dynamic Light Scattering

Routine Quality Testing of Blood Platelet Transfusions with Dynamic Light Scattering

Maurer-Spurej E, Labrie A, Brown K. Particles & Particle Systems Characterization, 2008; 25:99-104.

Extension of the current 5-day shelf life of platelet concentrates to increase the supply of this life saving blood product will require quality testing. However, no automated test exists to routinely measure the quality of platelet concentrates for transfusion. Platelet concentrates cannot be sampled and diluted. These practical limitations have prevented the routine use of optical methods for platelet quality testing. The Dynamic Light Scattering Platelet Monitor (DLS-PM) addresses these limitations. The DLS-PM is a portable instrument with a temperature-controlled sample holder to accommodate a wide range of sample containers. The challenges of small sample size, short light path through the sample, and accurate temperature control have been solved. The DLS-PM measures platelet size, number of platelet-derived microparticles, and the response of platelets to temperature changes, which are combined to calculate a platelet quality score. In this paper we introduce the DLS-PM and discuss the advantages and challenges for dynamic light scattering to become a clinically relevant, routinely used platelet test.

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